A bioactivity-leveling approach for component-specific evaluation in natural product extracts: Optimizing SARS-CoV-2 antiviral screening by controlling for pheophorbide A

The emergence of SARS-CoV-2 has intensified the search for novel antiviral agents, with plants representing a promising source due to the documented antiviral properties. Pheophorbides, chlorophyll breakdown products, have been demonstrated to impede viral en…